Expression profile of plasma exosomal microRNAs in women with polycystic ovary syndrome and control women

Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine-metabolic disorder. Epigenetic etiology is suggested to play an important role in PCOS pathogenesis, since it is hard to elucidate completely by genetic variations. Exosomal microRNAs (miRNAs) have recently been identified as a novel mechanism of intercellular communication, and a more stable regulator of gene expression compared with free miRNAs. The aim of this study is to detect the different expression profile of plasma exosomal miRNAs between PCOS patients and healthy controls. Plasma exosomal miRNA profiles from 15 PCOS women and 15 control women. All participants were recruited in Center for Reproductive Medicine, Shandong University, from January to June in 2017.