Ischaemic stroke metaGRS

A genomic risk score (metaGRS, a meta-score combining multiple GRSs) for ischaemic stroke, consisting of 3.2 million SNPs that had MAF &gt;1% in the UK Biobank British white subset and imputation INFO &gt;0.4 over the entire UK Biobank dataset.<br><br>Also provided is a version further excluding ambiguous strand SNPs (A/T or G/C), leaving 2.76 million SNPs. This score had very similar performance in the UK Biobank validation set in terms of association with age of ischaemic stroke.<br><br>The rsids, positions, and alleles are with respect to UK Biobank genotyping release 2 (hg19).<br><br>Also included are the SNP weights for each component GRS that contributed to the stroke metaGRS, as well as the weights for the metaGRS itself.<br><br>To apply the metaGRS scores to new data with plink use:<br>plink --bfile your_data \--score metaGRS_stroke_IS_MAF0.01_INFO0.4_exclATGC.txt 2 4 18 header sum<br>