Design and synthesis of nigranoic acid esters as anti-inflammation agents

Nigranoic acid, an A ring-secocycloartene triterpenoid, was constantly found to possess various biological activities, including anti-inflammation. In this study, fifteen new nigranoic acid ester derivatives were synthesised in good yields and assessed for their anti-inflammation activities. As a result, all the compounds including nigranoic acid could reduce NO production considerably (p