BPGM dimer isomerises 1,3BPG to 2,3BPG

Bisphosphoglycerate mutase (BPGM) is an erythrocyte-specific trifunctional enzyme. One of its functions is the isomerisation of 1,3-bisphosphoglycerate (1,3BPG) to 2,3-bisphosphoglycerate (2,3BPG) (Rose 1968). In red blood cells, 2,3BPG is the main allosteric effector of hemoglobin, binding preferentially to the deoxygenated hemoglobin tetramer, thus reducing oxygen affinity (Arnone 1972).

双磷酸甘油酸变位酶（BPGM）是一种红细胞特异性的多功能酶。其中一项功能是催化1,3-双磷酸甘油酸（1,3BPG）异构化为2,3-双磷酸甘油酸（2,3BPG）（Rose 1968）。在红细胞中，2,3BPG是血红蛋白的主要变构效应物，优先与去氧血红蛋白四聚体结合，从而降低其氧亲和力（Arnone 1972）。