Demographic, clinical, routine biochemical and genetic data of the subcohorts.

Demographic, clinical and biochemical data of patients with Parkinson’s disease non-demented (PDND) and Parkinson’s disease with dementia (PDD) are presented with median (range) or percentage of total. P-values were determined using the Wilcoxon rank sum test or the Fisher’s exact test. Aao, age at onset; ApoE4, at least one Apolipoprotein E4 allele; BDI, Beck Depression Inventory; CSF, cerebrospinal fluid; f, female; GSK3B, Glycogen synthase kinase 3 beta; HLA-DRA, Human leucocyte antigen/Major histocompatibility complex, class II, DR alpha chain; HSPA5, Heat shock 70 kDa protein 5; H&Y, Hoehn & Yahr stage; MMSE, Mini-Mental State Examination; p-tau, phospho-tau; SNCA, Synuclein alpha; STK39, Serine threonine kinase 39; t-tau, total tau; UPDRS, Unified Parkinson’s Disease Rating Scale.