Hsa-miR-1-2/miR-133a-1 cluster expression silencing by DNA hypermethylation triggers oncogenes contributing to prostate cancer aggressiveness

We developed a metabolic syndrome (MeS)-like disease model using C57BL/6J mice chronically fed with high fat diet (HFD) that were inoculated with TRAMP-C1 prostate cancer (PCa) cells to investigate the effect of a HFD on the expression of cancer-related miRNAs. In this dataset, we include the expression data obtained from TRAMP-C1 tumors developed in control diet (CD) versus high fat diet (HFD) C57BL/6J male mice. For differential expression analysis we used the Rank Product Method for two class unpaired data and a fold discovery rate (FDR) < 0.05 . C57BL/6J male mice were fed with a high fat diet (HFD) for 15 weeks, then injected s.c with TRAMP-C1 murine prostate cancer cells. Animals were sacrificed in the 27th week and tumor samples were processed, total RNA was obtained and hybridized with GeneChip® miRNA 4.0 Array (Affymetrix)