Copper-Catalyzed Arylation of Benzylic C–H bonds with Alkylarenes as the Limiting Reagents

A novel copper-catalyzed aryl­ation
of benzylic C–H
bonds with nucleo­philic aryl­boronic acids has been developed
that provides an efficient way to synthesize various 1,1-diaryl­alkanes
with a broad substrate scope and excellent functional group compatibility.
The reactions occur at room temperature using alkyl­arenes as
the limiting reagents, which allows access to the aryl­ation
of the more valuable and complex bioactive compounds.