rejectionCD4TRM Genome sequencing and assembly. Mus musculus strain:SCID | isolate:rejectionCD4TRM

TRM cells play an important role in local immune surveillance to prevent pathogen infection and participate in many diseases. But it is not clear whether TRM cells formed in non-lymphoid organs or tissues can mediate the rejection of other allogeneic organ transplants. By transplanting allogeneic skin or heart into SCID mice or Rag2 KO mice, in which induced CD4+ and/or CD8+ TRM cells containing MHC-matched or syngeneic skin was pre-transplanted, we studied With these cells residing in the skin, TRM cells will reject the allograft in the body. RNA-seq analysis and cytology experiments show that during the secondary immune response, the CD4+ TRM cells induced in the skin are conducive to differentiation into Th17-like functional polarization.