Z-DNA underlies the target choice of Aire by facilitating promoter poising [ChIPmentation]

NIAID Data Ecosystem2026-05-01 收录

胸腺上皮细胞

艾尔基因研究

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We profiled NELF and Aire binding in medullary thymic epithelial cells using ChIPmentation to investigate the logic of Aire's target choices Overall design: ChIPmentation of mTECs

创建时间：

2024-04-13

WT and Aire-KO B6 MEChi RNAseq profiling. WT and Aire-KO B6 MEChi RNAseq profiling

上皮细胞转录组

艾尔基因研究

Aire-sensitive genes exhibit a weak inclusion of alternative splicing events Overall design: Total RNA isolated by Trizol extraction from MHC-II high mTECs (pool of mice) was used to generate poly-A-s

NIAID Data Ecosystem60

Multiple subpopulations in medullary thymic epithelial cells are regulated by Aire with distinctive modes of gene regulations [bulkRNA-seq]. Multiple subpopulations in medullary thymic epithelial cells are regulated by Aire with distinctive modes of gene regulations [bulkRNA-seq]

胸腺上皮细胞

单细胞转录组学

Aire, a transcriptional regulator whose defect results in the development of autoimmunity, controls the transcriptome in the bulk of medullary thymic epithelial cells (mTECs) including the genes for s

NIAID Data Ecosystem30

Large-scale single cell mapping of the thymic stroma identifies a new thymic epithelial cell lineage [ChIP-seq]. Large-scale single cell mapping of the thymic stroma identifies a new thymic epithelial cell lineage [ChIP-seq]

单细胞测序

胸腺上皮细胞

T cell development and selection is orchestrated in the thymus by a specialized niche of diverse stromal populations. By transcriptional single cell sorting, we de novo characterize the entire stromal

NIAID Data Ecosystem30

GTF2I mutation induces metabolic alterations and cell transformation in thymic epithelial cells [II]. GTF2I mutation induces metabolic alterations and cell transformation in thymic epithelial cells [II]

胸腺上皮细胞

代谢重编程

The molecular mechanisms underlying the pathogenesis of TETs are poorly understood. Recently we reported a common missense mutation on GTF2I gene in thymic tumors and hypothesized that GTF2I mutation

NIAID Data Ecosystem40

Thymic epithelial cells require p53 to support their role in T-cell development and tolerance induction.. p53 in thymic epithelial cells homeostasis

胸腺上皮细胞

免疫耐受机制

Thymic epithelial cells (TECs) constitute crucial microenvironments for T-cell development and self-tolerance. Beyond its recognized tumor suppressive function, p53 regulates the differentiation of mu

NIAID Data Ecosystem30

Z-DNA underlies the target choice of Aire by facilitating promoter poising [ChIPmentation]

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