Association Analysis results.

The left panel shows the association results at 7 loci. For each gene, the strongest variant is listed first, and any second detected independent signal is listed with results from the conditional analysis (Materials and Methods). The column Type indicates whether the SNP was directly genotyped (Metabochip) or imputed using 1000G reference haplotype (1000G) or the Sardinian reference panel (Affy+Sanger). The right panel shows the association results for the GWAS SNPs previously described [5], the correlation with the top SNP listed in the left panel, and its p-value in the conditional analysis (Adjusted P-value).
aEffect sizes are standardized (see Materials and Methods), and represent the change in trait LDL-C values associated with each copy of the reference allele, measured in standard deviation units.
bSNP rs583104 is also 1 Kb from PSRC1 transcript.
cr2 = 0.967 with Metabochip second-independent SNP, rs429358. After adjusting for the two independent SNPs, rs7412 and rs429358, the p-value for rs4420638 was 0.5.