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Synthesis of N-Substituted Indole Derivatives via PIFA-Mediated Intramolecular Cyclization

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https://figshare.com/articles/dataset/Synthesis_of_N_Substituted_Indole_Derivatives_via_PIFA_Mediated_Intramolecular_Cyclization/3040168
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A variety of N-arylated and N-alkylated indole derivatives were synthesized by way of a phenyliodine bis(trifluoroacetate) (PIFA)-mediated intramolecular cyclization. This novel method allows for the construction of an indole skeleton by joining the N-atom on the side chain to the benzene ring at the last synthetic step. Other novel pyrrole-fused aromatic compounds can also be achieved by this method.
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2006-12-21
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