Parameter values for best fit of simulated anesthesia and cholinergic reversal.

Parameters from lowest cost fit (cost averaged across anesthetic levels) used to simulate anesthetic effects and cholinergic reversal. A/B-Series describe optimal values of best fit determined by the differential evolution algorithm for network connectivity parameters obtained when ACh effects are assumed constant (i.e., gKs is constant; A-Series) and when ACh effects are allowed to change with anesthetic concentration (B-Series). Px denotes scaled changes in synaptic conductance’s mediated by the x receptor (x = NMDA, GABA and AMPA) as described in Table 1. AR/BR-Series represent simulated anesthetic reversal, obtained by increasing ACh effects (decreasing gKs from A4/B4 levels) while keeping all other parameters constant.