Psychedelic drug effects on reactivity of the paraventricular nucleus of the hypothalamus and threat responding behavior

Psychedelics have experienced renewed interest following studies suggesting potential therapeutic effects in patients with affective disorders. While clinical results look promising, the neurobiological mechanisms underlying acute and prolonged effects of psychedelics remain unclear. Many psychiatric disorders involve hypothalamic-pituitary-adrenal (HPA) axis dysfunction. The paraventricular nucleus of the hypothalamus (PVN) is a midline hypothalamic nucleus that plays an integral role in HPA stress reactivity, autonomic functioning, social behavior, and many other affective processes. We investigated the effect of psilocin, the psychoactive metabolite of psilocybin, on PVN reactivity in Sprague Dawley rats. Psilocin increased stimulus-independent activity as measured by c-Fos expression in the PVN of male and female rats. Psilocin also increased PVN reactivity (ΔF/F) to an aversive air-puff stimulus in males but not females. PVN reactivity was restored at 2- and 7-days post-injection w..., Data were collected using TDT RZ5 real time processor and Anymaze., , # Psychedelic drug effects on reactivity of the paraventricular nucleus of the hypothalamus and threat responding behavior

[https://doi.org/10.5061/dryad.3ffbg79qr](https://doi.org/10.5061/dryad.3ffbg79qr)

Data set includes data files, Matlab structures, and Matlab scripts used to generate data structures containing values used in a currently submitted manuscript. These experiments included the use of an air-puff in conjunction with fiber photometry to track changes in reactivity within the PVN at acute and prolonged time points.

## Description of the data and file structure

Throughout all data structures, there is a Psilocin and Vehicle structure. If you open them you will see further organization based on the condition/day of recording. If you click on that you will see various data values that contain data points for each subject. In all data folders the rows correspond to values for an individual subject.

Data files:

1. COHORT 7 DARTERS_revision.xlsx: includes lists of subjec...