Transcriptome analysis of murine skeletal muscle of Nrf2 KO mice in space.

Our study aims to comprehensively understand the epigenetic effects induced by the space environment on mammals. To achieve this aim, we analyze the male WT and Nrf2 KO mice housed under environments as the microgravity (space environment) in Japanese Experiment Module (JEM) of the International Space Station (ISS) on orbit for 31 days. After recovered these mice on the ground, transcriptome analysis by next-generation sequencing technology is performed about each organ to examine alteration of gene expression in the space.