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A-485 induce significant decrease in MITF and MITF signature genes in melanoma cell lines.. A-485 induce significant decrease in MITF and MITF signature genes in melanoma cell lines.

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA478559
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Differential response to p300 inhibitor A-485 was observed in a panel of melanoma cell lines. Three melanoma cell lines were treated with A-485 and microarray was used to determine gene expession changes at 6 and 24 hours. Overall design: Melanoma cell lines, two sensitive and one resistant cell lines, were treated with A-485 to identify genes that are differentially modulated by A-485.
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2018-06-29
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