Table 4 in Chemical constituents derived from Artocarpus xanthocarpus as inhibitors of melanin biosynthesis

Table 4 Effect of compounds isolated from A. xanthocarpus on melanin content, tyrosinase activity, and cell viability of B16F10 melanoma cells.
CompoundsConcentration (µµ)Cell viability (% of control) aMelanin content (% of control)bTyrosinase activity (% of control)bControl100.0 ± 0.9100.0 ± 3.1100.0 ± 3.0OE- MSHnd123.3 ± 10.5 #122.1 ± 12.3 #140110.1 ± 3.763.2 ± 9.4 ⁄⁄78.7 ± 13.9 ⁄⁄24095.5 ± 4.350.8 ± 8.5 ⁄⁄105.8 ± 4.9 ⁄⁄310105.1 ± 2.464.3 ± 9.4 ⁄⁄111.7 ± 11.041097.3 ± 0.465.7 ± 4.7 ⁄⁄100.8 ± 6.4 ⁄5ndndnd68099.5 ± 7.8113.9 ± 12.6135.5 ± 3.078097.9 ± 0.796.0 ± 9.6 ⁄109.3 ± 18.4820102.0 ± 3.067.8 ± 111.6 ⁄⁄86.6 ± 3.1 ⁄980102.4 ± 8.4111.8 ± 10.9134.3 ± 7.71080100.5 ± 0.4100.0 ± 14.0 ⁄176.5 ± 4.911ndndnd122094.0 ± 1.3112.6 ± 19.3141.4 ± 12.2 ⁄1380100.9 ± 5.3134.9 ± 13.9 ⁄⁄160.2 ± 38.51420106.7 ± 0.579.1 ± 3.4 ⁄122.9 ± 16.5151075.2 ± 9.5#ndnd1620104.4 ± 8.692.6 ± 8.2 ⁄⁄120.2 ± 11.21710107.0 ± 11.075.9 ± 3.5 ⁄⁄75.6 ± 7.2 ⁄⁄181099.7 ± 1.972.0 ± 12.4 ⁄⁄81.9 ± 11.9 ⁄⁄194099.7 ± 1.991.8 ± 7.8 ⁄⁄91.0 ± 10.8 ⁄2080103.4 ± 7.290.6 ± 3.5 ⁄⁄144.3 ± 4.8 ⁄214095.2 ± 3.464.6 ± 8.9 ⁄⁄72.2 ± 7.5 ⁄⁄228098.5 ± 1.6108.5 ± 12.4118.1 ± 11.3Arbutin c300100.4 ± 0.776.4 ± 6.3 ⁄⁄73.8 ± 5.4 ⁄⁄Kojic acid c30098.9 ± 1.185.8 ± 6.8 ⁄⁄81.1 ± 13.7⁄⁄
Nd: not determined due to being inactive in mushroom tyrosinase inhibition or limited yield. Data represents the mean ± S.D. (n = 3–6). (#) <0.05 indicates significant differences from the control group. (⁄) <0.05, ⁄⁄ p <0.01 indicates significant differences from the OE- MSH treated group.
a Effect of compounds on cell viability of B16F10 melanoma cells.
b The inhibitory effect on melanin production and tyrosinase activity in B16F10 melanoma cells stimulated by 50 nM OE- MSH.
c Positive control.