Association of haplotypes derived from rs2856650, rs3740689 and rs10769258 with VT risk in two GWAS.

The meta-analysis of the AGT haplotype-associated ORs obtained in the two GWAS samples lead to an overall OR of 2.78 [2.01–3.81] (p = 4.72 10−10). In a combined analysis of the individual-level genotype data of the two GWAS, the AGT haplotype frequency was estimated to 0.054 and 0.019 in cases and controls, respectively. This led to a combined OR of 3.03 [2.23–4.10] (p = 8.96 10−13) compared to the most frequent GGT haplotype (with estimated frequency 0.330 and 0.343 in cases and controls, respectively).