Genetic heterogeneity between groups of individuals assigned to tissue-specific subtypes of BMI (or WHRadjBMI).

In the BMI analysis, β1 denotes the SNP-effect of an adipose eQTL on BMI in those individuals assigned to the adipose-specific subtype of BMI, β2 is the SNP-effect of a brain eQTL on the brain-specific subtype of BMI, γ1 is the SNP-effect of a brain eQTL on the adipose subtype and γ2 is the effect of an adipose eQTL on the brain subtype. We provide the mean magnitude of the effect sizes of a tissue-specific eQTLs on the BMI of the corresponding tissue-specific group of individuals (e.g., joint SNP-effect of the adipose eQTLs on the BMI of individuals with adipose subtype), and the p-values obtained from the Wilcoxon rank sum (WRS) right tail tests of effect heterogeneity. For each test, the alternative hypotheses are listed in parentheses, while the null hypothesis is the equality between the corresponding pair of parameters. These parameters are defined in the same way for the adipose subcutaneous (AS) and muscle skeletal (MS) tissue-specific subtype of WHRadjBMI and the same analyses are performed.