BIOGRID CURATED DATA FOR SOD1 (Saccharomyces cerevisiae (S288c))

Protein-Protein, Genetic, and Chemical Interactions for SOD1 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p and enters the nucleus under oxidative stress to promote transcription of stress response genes; human ortholog implicated in ALS; abundance increases under DNA replication stress and during exposure to boric acid; localization of a fraction to the mitochondrial intermembrane space is modulated by the MICOS complex

蛋白质-蛋白质、遗传和化学相互作用数据集，针对SOD1（酿酒酵母S288c）由BioGRID（https://thebiogrid.org）整理；定义：细胞质铜锌超氧化物歧化酶；解毒超氧阴离子；在葡萄糖中稳定Yck1p和Yck2p激酶以抑制呼吸；由Dun1p磷酸化并在氧化应激下进入细胞核以促进应激反应基因的转录；人类同源基因与肌萎缩侧索硬化症相关；在DNA复制压力下和硼酸暴露期间含量增加；部分定位到线粒体间隙空间的分布受MICOS复合物的调控。