Tumor-derived oxidative stress triggers follicle loss in breast cancer

Breast cancer is the common indication for ovarian cryopreservation. However, whether the grafting ovarian tissue meets the functional requirements and the need for additional interventions remains unclear. Here, we show abnormal serum hormones in breast cancer in human and tumor-bearing mice, and for the first time show that tumor induced loss of primordial and growing follicles and the number of follicles being lost to either growth or atresia. A gene signature of tumor-bearing mice demonstrates the disturbed regulatory network of steroidgenesis which link to mitochnondia dysfunction in oocytes and granulosa cells via PI3K signaling pathway. Comparative gene expression profiling analysis of RNA-seq data for control female balb/c-nude mice and breast tumor bearing-mice.