A MIV-150/zinc acetate gel provides significant protection against vaginal SHIV-RT infection.

The protected versus not protected animals in the treatment groups shown in Figure 2 and Figures S1 and S2 are summarized. Each symbol marks an individual animal as protected or not. The open symbols denote animals with atypical, low-level viral blips (see text). The data for the animals receiving the daily zinc acetate gels have been pooled since the protection was similar at the two time points (see Table S2). The data for the animals given zinc-containing gels (zinc acetate and MIV-150/zinc acetate) every other day (EOD) have been pooled since similar protection was observed under this regimen (see Figure 2B). The p values (Fisher's exact test) for protection and the percent protection relative to the carrageenan vehicle control group are provided.