Supplementary tables for Integrative multi-omics Mendelian randomization reveals biological targets on human longevity

1. The integrative multi-omics Mendelian randomization comprehensively explored and revealed nine targets among nine tissues having causal effects on longevity, including the previously reported LPA, APOE, NT-proBNP, CD14, haptoglobin, and granulin, and the newly identified PDAP1, cathepsin-F, and DNAJA4.2. A cascading effect of both the transcription and protein level of PDAP1 on human lifespan was identified, which might reduce lifespan by modifying sex hormones, adiposity, and epigenetic aging acceleration.3. Biologic pathway analysis highlighted functional genetic subclusters related to neoplasm, immune response, and cholesterol metabolism, which sheds light on potential drug targets that promote healthy lifespan.