Crystal structure of catalytic domain of TACE with hydroxamate inhibitor
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Crystal structure of catalytic domain of TACE with hydroxamate inhibitor Descriptor: ADAM 17, CITRIC ACID, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ... Authors: Mazzola, R.D, Zhu, Z, Sinning, L, McKittrick, B, Lavey, B, Spitler, J, Kozlowski, J, Neng-Yang, S, Zhou, G, Guo, Z, Orth, P, Madison, V, Sun, J, Lundell, D, Niu, X. Deposit date: 2008-09-03 Release date: 2008-09-23 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket. Bioorg.Med.Chem.Lett., 18, 2008
创建时间：
2008-09-03
