Distinct Metabolic Adaptation of Liver Circadian Pathways to Acute and Chronic Patterns of Alcohol Intake

We reveal differential reprogramming of the circadian transcriptome in the liver using acute versus chronic ethanol feeding. Specifically, rewiring of diurnal SREBP transcriptional pathway leads to distinct hepatic signatures in acetyl-CoA metabolism that are translated into the subcellular patterns of protein acetylation distinct to chronic exposure to ethanol. Therefore, distinct drinking patterns of alcohol result in differential circadian reprogramming that may contribute to ALD pathogenesis. Overall design: Examination of circadian transcriptome in mouse liver under acute and chronic ethanol feeding conditions.