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Transcriptomic profiling of MLL-ENL and delta YEATS mutant

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE211523
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To investigate the contribution of ENL YEATS domain and downstream sequences in MLL-ENL leukemogenesis program, we generated MLL-ENL and MLL-ENL ∆YEATS (ENL aa372-559) cell lines by retrovirally introducing these constructs into lineage negative hematopoietic stem and progenitor cells (HSPCs). We then perform gene expression profiling using dataset obtained from RNA-seq experiment of MLL-ENL and MLL-ENL ∆YEATS, with 2 technical replicates each.
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2023-02-27
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