Human SARM1 TIR domain bound to compound 22

Human SARM1 TIR domain bound to compound 22 Descriptor: 1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-3,4-dihydroxyoxolan-2-yl]-4-{(6P)-7-{[2-(dimethylamino)ethyl]amino}-6-[6-fluoro-4-(pyrimidin-2-yl)-1H-indol-2-yl]-1-methyl-1H-imidazo[4,5-c]pyridin-2-yl}pyridin-1-ium (non-preferred name), GLYCEROL, NAD(+) hydrolase SARM1 Authors: Dementiev, A, Johnson, Z.L, Olland, A.M. Deposit date: 2026-02-02 Release date: 2026-04-22 Last modified: 2026-04-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure-Based Discovery of Imidazo[4,5- c ]pyridine SARM1 Modulators Showing Paradoxical Activation. J.Med.Chem., 69, 2026