Dietary fatty acids interact with gut microbiota and TLR4 to promote colitis and colorectal tumorigenesis. Dietary fatty acids interact with gut microbiota and TLR4 to promote colitis and colorectal tumorigenesis

We show that oxidized LA, rather than LA itself,exacerbates colitis via Toll-like receptor 4 (TLR4)- and gut microbiota-dependent mechanisms.Administration of a diet containing oxidized LA, at low human-consumption levels, increases the severity of colitis and exacerbates the development of colorectal tumorigenesis in mice. Overall design: To prepare “un-oxidized corn oil”, freshly opened commercial samples of corn oil were purified by column chromatography.