Biologic characteristics of B-lymphoblastic leukemia correspond to immunoglobulin gene diversity [array]. Biologic characteristics of B-lymphoblastic leukemia correspond to immunoglobulin gene diversity [array]

We tested the relationship between IgH subclone diversity in B-ALL and the number of resolved chromosomal breaks as assessed by chromosome microarray analysis (CMA). Overall design: Given the role of off-target recombination activating gene (RAG) activity at non-IgH sites in promoting copy number aberrations (CNA) in B-ALL, we conducted CMA to test whether patients with RAG-mediated IgH subclone diversity demonstrate greater karyotypic variability.