A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids

Two sets of results files are included. Set 1. Txt files provide the results of the epigenomide association study for each of 3 lipid traits, 3 racial/ethnic subgroups followed by a trans-ethnic meta-analysis, and 4 models. Files are labelled as lipid.model.racial/ethnic_group.GC. The three lipid trais are HDL: high-density lipoprotein; LDL: low-density lipoprotein; TG: triglycerides. The three racial/ethnic groups are EA: European ancestry; AA: African ancestry; HA: Hispanic ancestry; ALL_wGOLDN: trans-ethnic. The suffix "GC" indicates that a genomic-control correction has been applied. Each file includes results for fixed effect meta-analysis as well as random effect meta-analysis where more than 1 cohort is available for analysis (p-value, beta, standard error). Each file also includes heterogeneity statitics where more than 1 cohort is meta-analyzed. Lastly, P values for each study included in the meta-analysis are provided. Please note these P values are followed by M values labelled as NA. Set 2. CSV files provide the results of the methylation QTL association meta-analyses for 30 CpGs found to be associated with one of three lipid traits in more than one racial/ethnic group. SNPs tested are those within 25kb upstream or downstream of each CpG. Both fixed efffect and random effect meta-analysis results are provided as well as heterogeneity results when more than 1 study contributes to the meta-analysis. Each file is labelled by CpG followed by the racial/ethnic group analysed: EA: European ancestry; AA: African ancestry; HA: Hispanic ancestry.