Reproducibility package for: Reproducibility Stress-Testing Reveals Fragility of an Alzheimer Disease-ALS ncRNA Biomarker Signature

This archive contains the manuscript-supporting reproducibility materials for the study “Reproducibility Stress-Testing Reveals Fragility of an Alzheimer Disease-ALS ncRNA Biomarker Signature.” The archive includes derived data tables, figure source data, manuscript-matched figure files, lightweight reproduction scripts, documentation, and environment requirements needed to support the manuscript tables and figures. These materials support reconstruction and stress-testing of a nominal five-ncRNA Alzheimer disease/amyotrophic lateral sclerosis overlap involving MEG9, ZMIZ1-AS1, SLC12A5-AS1, GUSBP1, and STRCP1. The included materials support analyses of dataset provenance, identifier harmonization, overlap sensitivity, direction-of-effect consistency, independent Alzheimer disease validation, and cross-disease transportability. The archive is intended to reproduce and document the manuscript-facing tables and figures, not to provide a full de novo raw-GEO reprocessing pipeline. Raw transcriptomic data are publicly available from the Gene Expression Omnibus under accessions GSE203206, GSE48350, GSE124439, GSE153960, and GSE33000.