Targeted sequencing based maternal whole blood expression changes with gestational age and labor in normal pregnancy. Targeted sequencing based maternal whole blood expression changes with gestational age and labor in normal pregnancy

Maternal plasama colected longitudinally were profiled using targeted sequencing (DriverMap™) (https://www.cellecta.com) to evaluate changes with gestational age and with labor in normal pregnancy. Overall design: The study included normal pregnancies with (TIL) (n=8) and without (TNL) (n=8) spontaneous labor at term. Half of the women in each group had 3 longitudinal samples taken from 12.1-40.3 weeks of gestation, while the other half of women had only one sample taken at term before delivery, for a total of 32 samples. Note that Sample_26 was considered contaminated and hence data for that sample was not included in downstream analyses.