Clinical and CSF data at baseline and at follow-up after one year of natalizumab treatment.

Median values are given and range within parenthesis. n = 27 unless stated otherwise. p refers to Wilcoxon signed rank test comparing baseline and follow-up.an = 25 since lumbar puncture was not done in two patients.bn = 24,cn = 23,dn = 22 (n was reduced from 25 due to technical errors or lack of sample volume).Abbreviations: CSF = cerebrospinal fluid; EDSS = Expanded Disability Status Scale; MSSS = Multiple Sclerosis Severity Score; MSIS-29 = Multiple Sclerosis Impact Scale; SDMT = Symbol Digit Modalities Test; wbc = white blood cell; MBP = myelin basic protein; NFL = neurofilament light protein; GFAP = glial fibrillary acidic protein; T-tau = total tauprotein; P-tau = phosphorylated tauprotein; N = normal reference values; NA = not applicable.