Clinical validation of next-generation sequencing approaches for pathogen diagnosis

The Chiu laboratory and UCSF-Abbott Viral Diagnostics and Discovery Center (VDDC) at University of California, San Francisco applies unbiased next-generation sequencing (NGS) approaches to identify known as well as novel pathogens in patient clinical samples with acute infections. Here we present clinical sample data used for validation and testing of NGS-based clinical assays for infectious disease diagnosis.