p-Y-IRS1,p-Y-IRS2 bind PI3K
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IRS1, IRS2 and IRS3 are all known to bind the regulatory subunit of PI3K via its SH2 domain, an interaction that itself activates the kinase activity of the PI3K catalytic subunit (Rivachandran et al. 2001).
已知IRS1、IRS2和IRS3均能与PI3K的调节亚基通过其SH2结构域结合,此结合本身即可激活PI3K催化亚基的激酶活性(Rivachandran等,2001年)
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