Non-synonymous substitutions in human-chimp divergence and human polymorphism data.

Column heads: identity of an amino acid change; the data for transitions is shown in the upper part of the table, transversions below. Columns: divergence data with macaque or orangutan as outgroup followed by diversity data computed from human non-synonymous SNP. CpG/⌝CpG: number of changes within/outside CpG context; CpGtarget/⌝CpGtarget: number of targets within/outside CpG context. CpGimpact impact of CpGs as calculated in formula 1. The nsSNP data shown here is based on the Applera data set using human-chimp alignments to determine the direction of the mutation.