Evaluating the impact of amino acid variants has been a critical challenge for studying protein function and interpreting genomic data. High-throughput experimental methods like deep mutational scanni
The goals were to characterize BaP-induced mutation spectrum and to integrate next-generation sequencing with the transgenic rodent gene mutation reporter assay.
This study was the first-known large-scale effort to uncover the mutational spectrum of head and neck cancers. We analyzed whole-exome sequence from 92 tumor-normal pairs and retained 74 of them for s
In our study of SARS-CoV-2 genomic mutation analysis we investigated on the variants and different types of mutations in the viral genome and compared them with the variants from the other regions of