Data from: Hepatotoxicity of isotretinoin in patients with acne and Gilbert's syndrome: comparative study

Objectives: The objective of our follow-up study is to evaluate liver
function tests (LFTs) and lipid profiles in patients with Gilbert's
syndrome treated with isotretinoin because of severe acne. Setting:
Dermatology outpatient clinics of three regional hospitals of Jaén
(Spain). Participants: Over 4 years, we included all patients diagnosed
with severe acne. Only 37 patients were identified, of which 11 had
Gilbert's syndrome. Interventions: All patients were treated with
isotretinoin and followed-up in our outpatient clinics after 10 and
20 weeks. Patients were subjected to an interview questionnaire which
included data on age, gender, complete blood count, coagulation profile,
fasting blood glucose, LFTs and lipid profiles. Data and results of
patients with severe acne and Gilbert's syndrome were compared with
those of 26 patients with only severe acne (control group). Primary:
outcome Blood analyses were repeated in the follow-up visits. Results: In
patients with Gilbert's syndrome, bilirubin levels showed substantial
decrease over the 20-week follow-up, with more decrease after 10 weeks.
None of the control group patients had significant increase in total
bilirubin levels after 10 and 20 weeks of follow-up. Liver enzymes were
maintained within normal levels in both groups. Both study groups did not
show significant pathological increase in lipid profile levels. LDL levels
were increased in the two study groups, but this increase was less
substantial in patients with Gilbert's syndrome. Conclusions: Our
preliminary results suggest that oral isotretinoin could be an effective,
safe treatment for patients with Gilbert's syndrome, and may lower
bilirubin levels in the first 10 weeks of treatment. Limitations of the
study include the small numbers of participants and the fact that it is
restricted to one region of Spain.