Palladium-Catalyzed Regio‑, Diastereo‑, and Enantioselective Allylation of Nitroalkanes with Monosubstituted Allylic Substrates

Pd-catalyzed
asymmetric allylic alkylation of nitroalkanes and
monosubstituted allylic substrates was performed to afford products
with two adjacent chiral centers and with excellent regio-, diastereo-,
and enantioselectivities. The usefulness of the protocol in organic
synthesis was demonstrated by transformation of the product to an
optically active homoallyl­amine, a 2,3-disubstituted tetrahydro­pyridine,
and an α,β-disubstituted amino acid derivative.