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Single cell RNA sequencing of naive and primed human pluripotent stem cells treated with SB431542

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https://www.ncbi.nlm.nih.gov/sra/ERP126408
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The aim of this experiment was to investigate the role of TGFß signalling in human pluripotency, looking at the effect of SB431542 (SB), a potent and selective SMAD inhibitor that blocks TGFß/Activin receptors ALK5, ALK4, and ALK7, on gene expression. We performed 10X sequencing in naïve and primed human pluripotent stem cells (hPSCs) during a time-course of SB treatment.
创建时间:
2023-10-13
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