Pmch

This gene encodes a preproprotein that is cleaved to produce three mature peptides: melanin concentrating hormone, neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). The proprotein is processed differently depending on the tissue where it is expressed. Melanin concentrating hormone is involved in the regulation of food intake, energy homeostasis, and sleep-wake behavior. Disruption of this gene is associated with resistance to diet-induced obesity. [provided by RefSeq, May 2013]

该基因编码一种前体蛋白，该蛋白经切割可产生三种成熟的肽链：黑色素浓缩激素、神经肽-谷氨酸-异亮氨酸（NEI）以及神经肽-甘氨酸-谷氨酸（NGE）。该前体蛋白的加工方式根据其表达的特定组织而异。黑色素浓缩激素参与调节食物摄入、能量稳态和睡眠-觉醒行为。该基因的破坏与对饮食诱导性肥胖的抵抗性相关。[由 RefSeq 提供，2013年5月]