Synthesis Studies on the Lomaiviticin A Aglycone Core: Development of a Divergent, Two-Directional Strategy

The
enantiomer of the bicyclic lomaiviticin aglycone A core was
prepared via a two-directional, divergent approach featuring (1) a
double Ireland Claisen rearrangement to establish key core bonds with
correct relative stereochemistry and (2) a double olefin metathesis
reaction to deliver both cyclohexene rings of the target.

通过双向发散策略，成功制备了具有正确相对构型的关键核心键合的环状洛马维提辛糖苷元A核，该策略包括：(1) 双重爱尔兰克莱森重排，以确立目标核心键合；(2) 双重烯烃交换反应，以提供目标分子中的两个环己烯环。