Additional file 1 of Sex steroid hormones and risk of breast cancer: a two-sample Mendelian randomization study

Additional file 1. S1. Exposure instruments to proxy hormone levels in the overall breast cancer incidence MR analysis. S2. The strength of the instruments for each hormone including the variance explained and the F statistic. S3. Hormone and breast cancer incidence associations using the alternative MR methods: MR Egger, weighted median, weighted mode and MR-RAPS. S4. MR intercept calculations to identify evidence of pleiotropy. S5. Genetic correlation results between hormones. S6. Exposure instruments to proxy hormone levels in the subtype specific MR analysis. S7. Exposure instruments to proxy hormone levels in the BRCA1 mutated TNBC MR analysis. S8. Power calculations for each hormone and overall and subtype specific BC analysis.

附加文件1。
S1. 利用暴露工具作为代理以分析整体乳腺癌发病率的激素水平。
S2. 每种激素的暴露工具强度，包括解释的变异性和F统计量。
S3. 使用替代性合并分析方法的激素与乳腺癌发病率关联：Egger合并分析、加权中位数、加权众数以及MR-RAPS。
S4. 进行合并分析截距计算以识别多效性证据。
S5. 激素间的遗传相关性结果。
S6. 在亚型特异性合并分析中，利用暴露工具作为代理以分析激素水平。
S7. 在BRCA1突变型三阴性乳腺癌合并分析中，利用暴露工具作为代理以分析激素水平。
S8. 对每种激素以及整体和亚型特异性乳腺癌分析进行效能计算。