Copper-Catalyzed Decarboxylation Cross-Coupling Cascade Reaction for Synthesis of Fused Dihydro-benzoxazinones

A protocol for a tandem copper-catalyzed intermolecular
decarboxylation
cross-coupling cascade between o-bromobenzoic acids
and proline or piperic acid has been disclosed. The developed protocol
allows access to a variety of synthetically useful fused benzoxazinones
scaffolds with high efficiency and good functional group compatibility.
A mechanistically sequential approach for the decarboxylation and
dehydration coupling process was presented.