Transcriptional and Post-transcriptional Regulation of Mitochondrial Functions in Yeast Strains. Saccharomyces cerevisiae S288c

Environment stresses have enforced adaptive evolution with or within species, leading great shifts on phenotypes. However, the genetic basis corresponds to the phenotypic changes is often elusive. In this study, we focused on two yeast strains, which diverges in many features, including growth rate, temperature tolerance and pathogenicity. To elucidate the molecular mechanisms that potentially responsible for the phenotypic diversity, we conducted both mRNA and ribosomal footprint profiling sequencing on these two strains. In addition, we also conducted mitochondria replacement between strains to investigate the adaptation of mito-nuclear interaction.