Ethanol challenge in resistant and sensitized mice is associated with striatal epigenetic-related genes regulation.

During 10 days, mice received daily i.p. injections of saline or ethanol (2 g/kg) solution. At day 17, 30 min after saline or ethanol challenge (2 g/kg), striata were isolated to perform real-time PCR (n = 4 per group). Only genes whose expression is significantly different between resistant and sensitized mice are represented and expressed as percentages of control (mean ± SEM). ↓ and ↑ represent a significant decrease or increase in gene expression, respectively. ↓,↑P<0.05, ↓↓,↑↑P<0.01, ↓↓↓,↑↑↑P<0.001, = P>0.05. Regulations that pass the Bonferroni correction are indicated in bold.