The mechanisms of RNA-binding proteins (RBPs)-mediated post-transcriptional regulation of pre-existing mRNAs, which is essential for spermatogenesis, remains poorly understood. Here, we identify a ger

NIAID Data Ecosystem30

A G-quadruplex-binding platinum complex induces cancer mitochondrial dysfunction through dual-targeting mitochondrial and nuclear G4 enriched genome

癌症靶向治疗

线粒体遗传调控

G-quadruplex DNA (G4) is a non-canonical structure forming in guanine-rich regions, which play a vital role in cancer biology and are now being acknowledged in both nuclear and mitochondrial (mt) geno

NIAID Data Ecosystem20

Anterograde Regulation of Nuclear-encoded Mitochondrial Genes and FGF21 Signaling by Hepatic Histone Demethylase LSD1

线粒体遗传调控

代谢疾病机制

Mitochondrial biogenesis and function are controlled by anterograde regulatory pathways involving more than one thousand proteins encoded by nuclear genome. Transcriptional networks controlling the nu

NIAID Data Ecosystem50

Gene expression analysis upon mtDNA depletion [RNA-seq]. Homo sapiens

线粒体遗传调控

代谢通路转录组学

The goal of the study was to understand whether mitochondrial-driven epigenetic changes regulate gene expression. Mitochondrial metabolism has been implicated in epigenetics but the extent to which th

NIAID Data Ecosystem30

Caenorhabditis elegans Raw sequence reads. Caenorhabditis elegans

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