Includes supplementary methods, Table S1 and Figures S1-S6.
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https://figshare.com/articles/dataset/_Metabolic_Reprogramming_for_Producing_Energy_and_Reducing_Power_in_Fumarate_Hydratase_Null_Cells_from_Hereditary_Leiomyomatosis_Renal_Cell_Carcinoma_/774294
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Supplementary methods for the protein extraction for fumarate hydratase activity assay and for the fumarate hydratase enzyme assay protocol. Table S1, Fractional enrichment of intracellular metabolites derived from [U-13C]-glucose or [U-13C]-glutamine in FH null and restored cells. Figure S1, Fumarate Hydratase Enzyme Activity Assays. Figure S2, 13C enrichment in [U-13C]-glucose-derived nucleotide ribose and fumarate indicate that glucose is a minor carbon source for fumarate but a major carbon source for ribose in FH null and restored cells. Figure S3, 13C labelling patterns of intracellular lactate and alanine indicate the importance of glucose as their carbon source in UOK262 and UOK262WT cells. Figure S4, 13C labelling patterns of nucleotide Ribose in UOK262 cells indicate that glucose is the main source of carbon for ribose synthesis. Figure S5, GC/MS measurement for total ribose. Figure S6, Hierarchical clustering of Papillary renal tumors and normal kidney based on the expression levels of ribose sugar metabolism genes. (DOCX)
创建时间：
2015-12-02
