Cerebral perfusion and cognitive decline in type 2 diabetes

This dataset was collected as part of a study to explore vasoregulation and blood flow in patients with type 2 Diabetes mellitus. It comprises cerebral blood, autonomic functions, laboratory and gait variables in 70 patients with type 2 DM and 70 healthy controls (50-85 years old). Diabetes mellitus is a prevalent, costly condition with high morbidity and mortality that affects nearly 6.3% of the population in the United States. Diabetes mellitus alters the permeability of the blood-brain barrier, thus affecting regional metabolism and microcirculatory regulation. Predictors of cerebrovascular complications of diabetes that are evidence-based on cerebral blood flow, MRI imaging, and cognitive testing are lacking.

Blood flow velocities were measured in the anterior and middle cerebral arteries using transcranial Doppler ultrasound. Cerebral vasoregulation was evaluated by comparing blood flow velocity responses during hypocapnia and hypercapnia, Valsalva maneuver, head-up tilt and sit-to-stand test using simultaneous recordings of cardiovascular variables, blood flow velocity in the anterior and middle cerebral artery using transcranial Doppler and respiratory variables. We applied continuous arterial spin labeling at 3 Tesla MRI to evaluate regional distribution of cerebral blood flow and vasomotor reactivity to CO2. Cognitive and executive functions were assessed via a battery of psychometric measures. Gait and balance were characterized from dynamics of foot pressure distribution and center of pressure displacement.

本数据集系为探究2型糖尿病患者的血管调节和血流动力学而收集。该数据集包含70例2型糖尿病患者及70名健康对照者的脑血流量、自主神经功能、实验室及步态变量（年龄介于50至85岁之间）。糖尿病是一种普遍存在、代价高昂且死亡率高的疾病，在美国几乎影响了6.3%的人口。糖尿病会改变血脑屏障的通透性，从而影响区域代谢和微循环调节。基于脑血流量、MRI成像和认知测试的证据，缺乏对糖尿病脑血管并发症的预测因子。利用经颅多普勒超声测量前交通动脉和大脑中动脉的血流量，通过比较低氧血症和低碳血症期间、Valsalva动作、头部抬高倾斜测试以及坐位至站立位测试时的血流速度变化，评估脑血管调节功能。我们应用3特斯拉连续动脉自旋标记MRI技术评估脑血流的区域性分布和血管对二氧化碳的反应性。通过一系列心理测量方法评估认知和执行功能。通过足部压力分布动态和压力中心位移评估步态和平衡。