C2C12 muscle cell atrophy induced by miR-155-5p. Mus musculus

This study investigated the role of miR-155 in skeletal muscle cells and its impact on muscle-related diseases, particularly muscular dystrophies. The study aims to identify the molecular targets of miR-155 in muscle cells and understand how its overexpression affects gene expression and muscle phenotype. Through in silico and in vitro methods, the study identified specific genes influenced by miR-155, including those associated with muscle atrophy and dystrophic conditions. Additionally, the research suggests that miR-155 may have a broader role in regulating biological functions in skeletal muscle, such as metabolism, cell cycle regulation, and the immune system, indicating its potential significance in muscle disorders.