GNPS - Integrated proteomic/lipidomics reveal that the swarming motility of Paenibacillus polymyxa is driven by phospholipid changes, surfactants, and flagellar specialization

To better understand the molecular-level details of the swarming phenotype in P. polymyxa,m this study was designed to use a bioinformatics approach to integrate proteomics and lipidomics datasets generated for P. polymyxa grown in liquid swimming culture bacteria vs. swarming on agar platesbacteria. Integration of omics datasets unraveled the growth condition dependent phospholipid metabolism and possible membrane remodulation. Further, this study identifies the possible roles of GHs, flagellar assembly, chemotaxis and production of wetting agents and surfactants in swarming motility along with the validation from gene expression using RT-PCR.